Irbesartan, one pill a day, has 5 applications besides lowering blood pressure. You must know!

The mechanism of action of Irbesartan is to relax vascular smooth muscle, resist Aldosterone secretion, reduce water and sodium retention, prevent fibroblast proliferation and endothelial cell apoptosis, play a role in stable blood pressure reduction by antagonizing the binding of angiotensin II and AT1 receptor, and also has the function of reversing cardiac hypertrophy, alleviating heart failure, preventing Atrial fibrillation, and improving insulin resistance in hypertensive patients.Irbesartan has good target organ protection and prevention of cardiovascular endpoint events for hypertensive patients, and has no adverse effects on glucose and lipid metabolism

The mechanism of action of Irbesartan is to relax vascular smooth muscle, resist Aldosterone secretion, reduce water and sodium retention, prevent fibroblast proliferation and endothelial cell apoptosis, play a role in stable blood pressure reduction by antagonizing the binding of angiotensin II and AT1 receptor, and also has the function of reversing cardiac hypertrophy, alleviating heart failure, preventing Atrial fibrillation, and improving insulin resistance in hypertensive patients.

Irbesartan has good target organ protection and prevention of cardiovascular endpoint events for hypertensive patients, and has no adverse effects on glucose and lipid metabolism.

What are the indications of Irbesartan? What diseases can be treated? What are the specific advantages? What are the adverse reactions and precautions?

1Indications of Irbesartan? What diseases can be treated?

1. Primary hypertension: It relaxes vascular smooth muscle by antagonizing the binding of angiotensin II and AT1 receptor, so as to inhibit Vasoconstriction, reduce vascular resistance, reduce Aldosterone secretion, and steadily reduce blood pressure for primary hypertension. It is generally applicable to patients with moderate hypertension. For patients with severe hypertension, Hydrochlorothiazide or Amlodipine can be used together to enhance the antihypertensive effect and reduce side effects.

2. Hypertension with nephropathy: including diabetes nephropathy and non diabetes nephropathy, Irbesartan can improve renal hemodynamics, reduce renal vascular resistance, selectively expand efferent Arteriole, reduce glomerular pressure, reduce Proteinuria, increase Renal blood flow and glomerular filtration rate, thus protecting the kidney and delaying the process of chronic renal insufficiency.

2. Hypertension with type 2 diabetes: Irbesartan can improve glucose metabolism and prevent diabetes patients from developing micro Proteinuria to large Proteinuria, which is suitable for hypertension patients with diabetes.

3. Hypertension with coronary heart disease: Irbesartan can reduce left ventricular myocardial hypertrophy, inhibit cardiomyocyte proliferation, and delay or reverse myocardial hypertrophy.

4. Hypertension with heart failure: In the treatment of patients with heart failure, ACEI drugs are first-line drugs, and Irbesartan can replace patients with cough and metabolic syndrome caused by ACEI drugs.

5. Replace the dry cough caused by ACEI: Irbesartan can replace the cough and other symptoms caused by ACEI drugs due to blocking the degradation of Bradykinin system.

6. Replacement of lower limb edema caused by Amlodipine: patients with lower limb edema caused by long-term use of Amlodipine can use Irbesartan as an alternative treatment to reduce blood pressure.

Irbesartan is suitable for patients with hypertension complicated with diabetes, kidney disease, coronary heart disease, heart failure, Proteinuria or micro Proteinuria.

IIAdvantages of applying Irbesartan

2. Protective effect of target organs: Long term high blood pressure can easily cause damage to target organs, especially to the heart, brain, kidneys, and other organs. Irbesartan has a protective effect on target organs and is the preferred drug for hypertension with type 2 diabetes nephropathy, coronary heart disease, nephropathy, Proteinuria or micro Proteinuria.

3. It can prevent Atrial fibrillation, reduce the incidence of atrial fibrillation and stroke.

4. The bioavailability of Irbesartan is higher than that of most sartans, up to 60%~80%, with a long half-life of 11-15 hours, a long action time, stable blood pressure reduction, taking it only once a day, and high patient compliance.

In general, Irbesartan is a drug with high safety, stable effect and mild side effects among antihypertensive drugs. Therefore, it is also widely used in clinical practice.

1. Specification: Irbesartan usually has 75mg, 150mg and 300mg.

2. Usage and dosage:

(1) The initial dosage of the booster is 150mg, once a day. If the condition is severe, it can increase to 300mg once a day.

(2) For hemodialysis and patients over the age of 75, the initial dose can be considered as 75mg once a day.

(3) For hypertensive patients with type 2 diabetes, the initial dose of treatment should be 150mg once a day, and increased to 300mg once a day, as a better maintenance dose for treating kidney disease.

(4) For patients with renal dysfunction, there is no need to adjust the dosage.

(5) Patients with insufficient blood volume or sodium should be corrected before using Irbesartan.

(6) For patients with liver dysfunction, there is no need to adjust the dosage for patients with mild to moderate liver dysfunction, and there is currently no clinical data available for severe liver dysfunction.

Irbesartan is a drug for treating hypertension, and the specific dosage should be individualized. Patients should consult the instructions or take it according to the doctor's advice, and the dosage should not be adjusted at will.

In general, Irbesartan has few adverse reactions, which are generally mild or self limiting.

3. Very rare cases include hyperkalemia, headache, tinnitus, loss of taste, abnormal liver function, hepatitis, myalgia, Arthralgia, etc.

4. Before starting treatment, insufficient blood volume or sodium deficiency should be corrected.

5. Pay attention to the changes of blood Blood urea nitrogen, serum creatinine and blood potassium during taking.

6. Irbesartan cannot be excluded from the body through hemodialysis.

7. Prohibited for pregnant women and lactating women.

8. Currently, there is no medication safety data for patients under the age of 18.

9. In case of Hypotension, bradycardia or tachycardia caused by taking Drug overdose, seek medical treatment in time.

10. Be alert to the fact that Irbesartan drugs contain "azide" impurities, which may cause cancer in excess. In 2018, 2019 and 2021, Irbesartan containing "azide" impurities in many countries will be recalled.

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