One medication per day - Daggliflozin

Mechanism of actionHypoglycemia: Increase the excretion of glucose in urine.Lowering blood pressure: expelling sodium and diuresis

Mechanism of action

Hypoglycemia: Increase the excretion of glucose in urine.

Lowering blood pressure: expelling sodium and diuresis.

Reduce uric acid: Promote uric acid excretion.

Weight loss: It can increase urine excretion of glucose by 50-80g/d, which is equivalent to consuming 200-320 kcal of calories.

Heart and kidney protection: Reduce blood sugar, blood pressure, diuresis, inhibit the neuroendocrine system, protect blood vessels and kidneys through multiple mechanisms, and improve the prognosis of patients with chronic heart failure and kidney disease.

Indications (spanning the three major departments of endocrine, cardiovascular, and kidney disease)

1. Type 2 diabetes

2. Heart failure

3. Chronic kidney disease

Recently, the European Commission has expanded the indications for dapagliptin to heart failure with total ejection fraction, including heart failure with mild decrease in ejection fraction (HFmrEF) and heart failure with preserved ejection fraction (HFpEF).

The use of dagglinide in diabetes and chronic heart failure is on the rise.

Adverse drug reactions

1. May cause respiratory discomfort such as nasopharyngitis and cough.

2. Urinary tract infections may occur. During medication, if discomfort such as frequent urination, urgency, or pain occurs, timely medical attention is required.

3. When used in combination with other hypoglycemic drugs (insulin, insulin secretagogues), hypoglycemia may occur, and blood glucose levels should be closely monitored during the medication period. And carry candy with you to quickly replenish glucose in case of hypoglycemia.

matters needing attention

1. It is forbidden for patients with type 1 diabetes and gestational diabetes; Patients with definite diagnosis of diabetes ketoacidosis should stop using it immediately.

2. Ketone acidosis is rare, and close attention should be paid to the occurrence of nausea, vomiting, or the smell of rotten apples during breathing during medication. Urgent medical attention should be sought.

3. During the initial stage of medication, close attention should be paid to whether there are symptoms such as itching and rash. If any rash (redness or erosion) related to the mucous membrane (conjunctiva, lips, external genitalia) occurs, especially if the patient has tenderness, redness, swelling symptoms in the genitals or perineum, accompanied by fever, discomfort, pain, etc., it is recommended to seek medical attention immediately.

4. Patients with recurrent urinary and reproductive infections within six months are not recommended for use; During the medication period, increase drinking water in moderation, pay attention to personal external genital hygiene, maintain smooth urination, and reduce the occurrence of infections.

5For taking diuretics (especially medullary diuretics)Elderly patientsDaggligin should be used with caution, because it can cause osmotic diuresis, lead to hypovolemia, and increase the risk of acute renal injury.

6. Disabled for dialysis patients.

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