Oversatiety hurts, hunger cures all diseasesAs early as the Ming Dynasty, medical experts realized the many benefits of "eating less", and Taoism even invented the technique of clearing valleys to prolong life. Nowadays, the benefits of "eating less" on the human body have been continuously affirmed by scientists from a more rational perspective

Oversatiety hurts, hunger cures all diseases

As early as the Ming Dynasty, medical experts realized the many benefits of "eating less", and Taoism even invented the technique of clearing valleys to prolong life. Nowadays, the benefits of "eating less" on the human body have been continuously affirmed by scientists from a more rational perspective. A study by the University of Southern California in the United States even concluded that fasting for 48 hours may restart the immune system.

01. Fasting for 48 hours, immune system restart?

The immune system is the "bodyguard" of the human body, capable of blocking over 90% of pathogenic factors. However, as age increases, the immune system frequently malfunctions, leading to the invasion of pathogens into the human body. In 2014, the University of Southern California published a study in the top scientific journal Cell,The immune system of elderly mice that have not eaten for more than 48 hours miraculously "restarts".

Researchers divided 18 month old (equivalent to 56 years old in humans) mice into two groups: AB and group A. Group A was the experimental group and received a dietary cycle intervention of "fasting refeeding" for 48 to 72 hours at a time; Group B eats normally and is the control group.

Subsequently, the researchers administered the same dose of chemotherapy drugs to both groups of mice to damage their hematopoietic function. Surprisingly, in mice on a normal diet, immune indicators such as white blood cells and lymphocyte counts remained in a "collapsed" state;After a period of fasting in the experimental group of mice, the above indicators were significantly improved.

That is to say, the "fasting re feeding" cycle pattern helped Group A mice resist the "toxicity" of chemotherapy drugs, not only did it not damage hematopoietic function, but also promoted the reconstruction of hematopoietic function.

Short term fasting can increase the activity of SIRT1 (longevity protease) in the human body, but long-term fasting can have the opposite effect.

Scientists further stated, "Eating less is an inherent principle for improving health, and there is no data to support the optimal duration of fasting

02. The underlying mechanism is revealed: cells starve and eat themselves

Another professional biological term for fasting is calorie restriction. In 1935, biology professor McCay discovered that limiting the body's calorie intake can induce autophagy - where cells eat themselves, while viable cells eat "dying" cells, making the cellular defense system more active and maintaining the body's youth.

Relying on the cell principle, there are also emerging technologies such as "unblocking collaterals" that have gradually landed, which has slowed down the decline of the body in a more rigorous and popular way, and has been supported by multiple rounds of clinical data from the University of Tokyo and the Chinese Academy of Sciences.

According to relevant papers in Cell and Nature, the average age of middle-aged participants in the experiment was about 55 years old. After 7 days of intervention, telomeres, cardiovascular endothelial cells, and mitochondria related to aging showed a positive trend, even exceeding the level of middle-aged and young people.The SIRT1 protease, which was activated through fasting, remained active throughout.

With the support of scientific research, due to the rising tide, Changluo has sparked a heated discussion in the middle-aged men's circle. On the platform of Danjing JD East, it handed over millions of answers overnight.

Fasting is too harmful for a stomach patient like me. I can't even afford to skip a meal, but two maintenance supplements with a meal are much more convenient, "said Mr. Wang, a 35 year old programmer from a large factory.

However, the experimental research on "one meal a day prolongs the survival period by 28%" and "fasting activates brain neurons" is still continuing. Perhaps in the near future, scientists can give specific application scenarios and applicable populations to amplify their positive effects at the cellular level.

At present, the 168 therapy (no food for 16 hours, free to eat for the remaining 8 hours) has emerged among the wealthy, with domestic actors Shen Teng, Gu Tianle, and football star James being loyal supporters. However, many experimenters have expressed that 'if you don't persist, you will rebound', and the scientific community's explanation and response to this approach are still in the experimental stage.

03. Centenarians breaking 50000: Just the beginning

With the rapid development of modern science and technology, the average life expectancy of Chinese people has nearly doubled from over 40 to 77 years old in the past century. Not only has the average life expectancy made a qualitative leap, but the number of centenarians is also increasing year by year. According to data from the Health Commission in 2022, the number of surviving centenarians in China has reached 50000, an increase of nearly 5000 compared to the previous year.

Analysts at Bank of America Merrill Lynch said:Scientific knowledge is doubling in 73 days, and a revolution in "technology and humanity" is coming.Not only are relatively mature intervention methods such as Changluo Yin, but the techniques favored by PayPal founder Peter Thiel, such as blood exchange surgery, and the gene rearrangement technique of the world's richest man Bezos Heavy Warehouse, are all being intensively tested

In the book "Singularity Approaches", Ray Kuzweil states that when explosive scientific and technological advances reach the singularity, unimaginable changes can occur, and human biological limits may be surpassed to reach a state of immortality. Where will we be when this critical point approaches?

Famous scholars once proposed in "Singularity Approaching" that when technological development approaches the 'singularity', it will bring unexpected changes, even surpassing human biological limits and achieving longevity. With the continuous development of technology, what will be the future?

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